Articular Chondrocyte Mechanics at Different Loading Rates
نویسندگان
چکیده
INTRODUCTION Mechanical impact loading is known to cause cell death and to lead to the onset and progression of osteoarthritis [1]. In order to understand why in-situ cells die readily following impact loading but remain unaffected when the same load is applied at a slow rate, we used a Finite Element model of articular cartilage and chondrocytes to study the in-situ cell mechanics, which cannot be measured experimentally, especially at impact loading rates, with present day technology. The objective of this study was to investigate the effects of strain rate on in-situ chondrocyte mechanics. We hypothesized that tensile strain rates on cell membranes hold the key to explaining cell deaths at high loading rates.
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